Chiral diamines can asymmetrically activate carbonyl groups via iminium, enamine or dual hydrogen-bond activation. Using such approaches, chiral diamines have been shown to catalyse a variety of asymmetric conjugate reactions with high levels of observed enantioselectivity.
Chiral diamines have been used as ligands in a number of enantioconvergent alkyl-alkyl nickel-catalysed Suzuki cross couplings. The work featured in this section is from the group of Prof. Gregory C. Fu.
Monoprotected amino acids have been used as ligands in a number of palladium-catalyzed C-H activation. The work featured in this section is from the group of Prof. Jin-Quan Yu.
Possessing both hydrogen bond donor and acceptor motifs, guanidines have been commonly used as a design element in systems of molecular recognition. As well, guanidine’s propensity to form hydrogen bonds and its strong basicity have been exploited in the design of organocatalysts for novel enantioselective reactions.
Cantat et al. have shown that guanidines can catalyse functionalisations and reductions of carbon dioxide.