Diaza-Cope Rearrangement


Mother diamine is highly versatile for making chiral diamines.

1. React with aldehydes to give a wide variety of of chiral diamines.

2. Reaction is highly stereospecific (>99% ee)

3. Reaction takes place rapidly under mild conditions

4. Multistep in a one pot reaction without protecting groups


Video of mother-to-daughter transformation in real time  is shown below!